2013年11月28日星期四

2013 The Most Beautiful Youth with Filial Piety China

Dr. An Yihua is handing Out Awards to Huang Feng
Dr. An Yihua was invited to attend the wards ceremony of a large-scale public welfare activity“2013 The Most Beautiful Youth with Filial Piety”(2013 最美孝心少年).
A 14 years old girl Huang Feng (黄凤) was elected as one of the 2013 The Most Beautiful Youth with Filial Piety. Her Father Huang Zhiren, a spinal cord injury patient, received Stem Cell Treatment in the General Hospital of Armed Police Forces,China freely.

Touching Story of Huang Feng

Touching Story of Huang Feng
Because of an accident, Huang Feng’s Father get a spinal cord injury leading to high paraplegia. Then her parents divorced and her mother married again. At that time, Huang Feng is Only 6 years old and begin to support the family taking care of her father and elder grandma. Until now 8 years passed, Huang Feng never stopped finding treatment for her father wishing her father can get better. In May. 2008, Huang Feng together with her grandma took her father to Shanghai City for treatment. There is no plane, no train and even no car for Huang Feng, she used a iron bed with wheels taking her father to Shanghai from Anhui province. Fortunately, kind hearted driver on their way helped them taking they three to Shanghai. After they arrive in Shanghai, Huang Feng went begging and asking some hospitals to treat her father. However, the result is desperate. In April, 2010, Huangfeng took her father to Beijing for treatment, fortunately this time Huang Feng met Dr. An the director of stem cell center of the General Hospital of Armed Police Forces, China. Dr. An successfully did stem cell treatment for Huang Feng’s Father. Currently, her father’s condition get much improved such as muscle strength, Bowel and bladder dysfunction, Loss of sensations, Reduced ability to regulate heart rate, blood pressure, sweating, and body temperature. On 9th, Jan. 2014, Huang Feng will take her father again to Beijing For the second treatment course. Huang Feng said that no matter how hard it is, I will try best to study hard. In the future, I will go to senior school and university together with my father. The place having my father is my home. Best wishes for this strong girl and her family.

2013年11月27日星期三

A Case of Cerebral Palsy with Stem Cell Treatment

A Case of Cerebral Palsy with Stem Cell Treatment
Below is a case treated last year. Every 1-2 months we will make a follow up to discharged patients. Currently, according to her mom’s feedback, Wajd now can walk by himself slowly without help. He can use his hand take food. He can have social communication with his other people. Hope Wajd can make more improvements in the future.

Name: Wajd
Sex: Male
Country: Saudi Arabia
Age: 4 years
Diagnoses: 1.Cerebral palsy 2. Pulmonary infection 3. Asthma 4. Hyperthyroidism 5.Allergic eruption
Admission Date: 2012-04-27
Days Admitted to the Hospital: 21

Before treatment:
The patient was born when his mother was 36 weeks pregnant. 5 days after birth, the patient suddenly suffered from apnea. Then the patient suffered from a growth development delay and cognitive impairment. He was sent to a local hospital and was diagnosed with cerebral palsy. The patient suffered from poor nutrition after the onset of his disease. He also had a delay in both his mental and motor development. His heaviest weight was 9Kg. The patient underwent a gastrointestinal fistula operation and had an adjustment in his diet. After treatment, the patient's weight clearly increased. His nutrition was better than before. He was in a better mood and his motor functions improved. From the onset of disease, the patient was in poor spirits. His intelligence development and motor function development were delayed. His main diet was milk. He slept poorly, ha urinary incontinence and his stool was irregular. He had constipation and had defecation every several days. The patient could not turn over, crawl or walk by himself. He had a speech disorder and only could say simple words like "Daddy" "Mum" and "Water". The patient had normal comprehension abilities and had simple communication abilities with family members. His emotional responses were normal.

Admission PE:
Temperature: 40 degree. Br: 39/min; Bp: 108/68 mmHg, Hr: 146/min, Height: 76cms, weight: 11 kgs. His development was slow, his diet was poor. His skin was normal, with no yellow stains. There was obvious congestion in his throat. His tonsils were slightly swollen. He had thorax ectropion. The respiratory sounds in both lungs were rough. There was extensive wheeze rale in both lungs. There was moist rales in the right lung. This was accompanied by the suprasternal fossa being sunken when breathing. His heart sounds were strong. He suffered from tachycardia, the heart rate: 146/min. The cardiac rhythm was regular, with no obvious murmur in the valves. Abdominal distension, with stool mass in abdomen. The abdomen had a tympanitic note when we touched it. The liver and spleen were not touched under the rib.

Nervous System Examination:
Wajd was alert but he was not in good spirits. He had mental strain and was irritable. He had a speech disorder. His comprehension was still decent. The diameter of both pupils was about 3.0mms. Both pupils had sensitive responses to light stimulus. The position of his eyes was not symmetrical. The movement of his eyeballs was clearly restricted. The forehead wrinkle pattern was symmetrical. Bilateral nasolabial sulcus was equal in depth. The tongue was shifted to the right side. The gingiva in upper jaw was presented with black color, only had black teeth stand out gum. He had difficulty moving his neck was poor and the muscle strength of his neck was weak. He had a poor ability of supporting his head in a seated position. The muscle strength of his waist and back was poor. He could not turn over or maintain a seated position by himself. The patient had a poor ability to grasp objects. His whole body presently was spastic and his chest twisted to the right side. He could not complete the muscle strength examination.
The muscle tone of four limbs was higher than normal. His posture was in a flexion position. The abdominal reflexes could be elicited. The tendon reflex of both upper limbs was low. The patellar tendon reflex of both lower limbs was low. Bilateral achilles reflex was low. Bilateral palm jaw reflex was positive. Bilateral Babinski sign was positive. The patient suffered from hyperpyrexia before admission and the patient had pulmonary infection and asthma history.

Treatment:
After admission, Wajd received the relevant examinations. The patient received nerve regeneration treatment and Stem Cell Treatment. The patient received treatment to anti-infection positively, control asthmatic attack, promote sputum discharge and enhance organisms' immunity. Then patient received treatment to improve the blood circulation in order to increase the blood supply to the damaged nerves, activate autologous stem cells and to nourish the neurons. As for the Stem Cell Treatment, PhD. Wang Bo made suitable treatment plan for Wajd choosing four times Lumber Injection because of his young age and the brain and examination.

Post Treatment:
At present, the patient's rash has faded away gradually. The patient's pulmonary infection has been corrected. His asthmatic attacks have been alleviated obviously. His vital signs:Bp:90/60mmHg, Hr:118/min, Br:24/min. Temperature: 36.6 degree. Height:76cm, weight:11Kg. Neuron motor function aspects: his emotions are more stable. His emotional responses are more stable than before. The myospasm of his chest and four limbs has clearly been alleviated. The twisted position of his chest and four limbs has been corrected. The movement of his pupils is more sensitive than before, especially when moving to right side. His head also has more flexible movement towards the right side. With some assistance, the patient has stronger muscles to support his head. The muscle tension of his four limbs has clearly been reduced.

The Nobel Prize in Physiology or Medicine 2012

The Nobel Prize in Physiology or Medicine 2012
                   The Nobel Prize in Physiology or Medicine 2012

                                      to
                        John B. Gurdon and Shinya Yamanaka
for the discovery that mature cells can be reprogrammed to become pluripotent

The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings have revolutionised our understanding of how cells and organisms develop.

John B. Gurdon discovered in 1962 that the specialization of cells is reversible. In a classic experiment, he replaced the immature cell nucleus in an egg cell of a frog with the nucleus from a mature intestinal cell. This modified egg cell developed into a normal tadpole. The DNA of the mature cell still had all the information needed to develop all cells in the frog.

Shinya Yamanaka discovered more than 40 years later, in 2006, how intact mature cells in mice could be reprogrammed to become immature stem cells. Surprisingly, by introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, i.e. immature cells that are able to develop into all types of cells in the body.

These groundbreaking discoveries have completely changed our view of the development and cellular specialisation. We now understand that the mature cell does not have to be confined forever to its specialised state. Textbooks have been rewritten and new research fields have been established. By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy.

Sir John Bertrand Gurdon, (born October 2, 1933) is a British developmental biologist who was the first to demonstrate that egg cells are able to reprogram differentiated (mature) cell nuclei, reverting them to a pluripotent state, in which they regain the capacity to become any type of cell. Gurdon's work ultimately came to form the foundation for major advances in cloning and stem cell research, including the generation of Dolly(the first successfully cloned mammal) by British developmental biologist Sir Ian Wilmut and the discovery of induced pluripotent stem (iPS) cells by Japanese physician and researcher Shinya Yamanaka��an advance that revolutionized the field of regenerative medicine. For his discoveries, Gurdon was awarded the 2012 Nobel Prize in Physiology or Medicine, which he shared with Yamanaka.

Shinya Yamanaka (born September 4, 1962) is a Japanese physician and researcher of adult stem cells. He serves as the director of Center for iPS Cell Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University; as a senior investigator at the UCSF-affiliated J. David Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also the current president of the International Society for Stem Cell Research (ISSCR).He received the Wolf Prize in Medicine in 2011 with Rudolf Jaenisch; the Millennium Technology Prize in 2012 together with Linus Torvalds.
In 2012 he along with John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells.

2013年11月26日星期二

Touching Scene Happened in Dr. An's Office

The Sad Mom Behind Dr. An's Assistant
A touching scene I saw yesterday when I was making diagnosis with Dr. An Yihua the director of Stem Cell Center in the General Hospital of Armed Police Forces, China. One child's mom tears down when she describe her child's illness condition because her child is still in ICU. Her son fell off from the second floor and damaged spine T5 and T6 seriously. Currently, the patient is in one hospital of Henan province which is far from Beijing City. Her parents come to Beijing and want to consult whether her son can transfer to the General Hospital of Armed Police Forces and receive stem cell treatment as soon as possible.However, Dr. An advice first improve low blood pressure and lung infection and then the patient can transfer to our hospital for stem cell treatment. Wishing the 17 years old boy can pass the critical stage. As we know that Spinal Cord Injury can lead to sequela such as Bowel and bladder dysfunction, Muscle weakening and atrophy, Loss of voluntary muscle movement, Breathing difficulties, Loss of sensations, Sexual dysfunction etc. The application of Stem Cell Treatment in the General Hospital of Armed Police Forces China has been treated 1596 such cases and the efficiency rate is 87.6. If you want to contact Dr. An for case analysis, you can contact me via email: stemcelltech.cn@gmail.com

Stem Cells Gives Hope to Patients with Cerebral Palsy

Prof. An Yihua and His Doctoral Tutor Prof. Wong
Today I have an opportunity to make diagnosis with Dr. An,the Director of Stem Cell Center in the General Hospital of Armed Forces, China.This morning, Dr. An Yihua diagnosed 11 patients with central nervous system diseases such as infantile cerebral palsy, spinal cord injury, Motor Neuron Injury, Cerebral palsy combined with epilepsy etc. I feel sad when I am seeing the very young children and their worrying relatives.Most of them have already saw many hospitals and tried different ways treatment.I see different reactions from the parents. Some of them feel very excited because they heard Dr. An said their baby has big chance to stand up with stem cell treatment. Some of them feel doubt about the treatment result and ask a guarantee. Yes, we understand them but there is no any hospital can give you a 100% treatment guarantee. Then Dr. An will let them go to the ward area to talk with other patients and make the last decision by themselves. We give chance to every patients to know the real treatment result and then make the decision for treatment.
Wiating for Their Registration Number
Here I show a picture taking at 7:30 am. when I am waiting for Dr. An. Every Tuesday and Thursday morning from 8:30 to 11:30 Dr. An will make diagnosis for patients from all over the country. Therefore, patients come early to make clinic registration. If you see any patients with central nervous system diseases, you can contact me via email. stemcelltech.cn@gmail.com

2013年11月25日星期一

Stem Cell Treatment for Central Nervous System Diseases

Stem Cell Treatment for Central Nervous System Diseases
Research about the function and application of stem cells in treating human diseases has been lasting for several decades. There is a big dispute about the research of stem cells in the world. Stem Cell research is banned in some countries because of the invasion of human rights, especially for the research of Embryonic Stem Cells (ESCs).However, the research of stem cells has never stopped.
In China, stem cell treatment has been used in clinic formally for almost 10 years. In 2003, the General Hospital of Armed Police Forces, China has the first STEM CELL CENTER in the world with the first-class researching equipment.During the 10 years' clinical application, stem cells treat more than 6000 patients with Child Cerebral Palsy, spinal cord injury, Multiple System Atrophy, Post-traumatic brain syndrome,etc. According to follow up, patients have continuous improvements sensory function, motor function, language function and intelligence and muscular tension.
From Nov. 17 to Nov. 22, 2013 In this week's Editor's Pick, Jayaraj Rajagopal and colleagues, describe their findings studying the ability of mouse airway epithelia to dedifferentiate and contribute stem cells for the adult airway. This study may be part of a more generalizable mechanism whereby differentiated cells may dedifferentiate and contribute to the regenerative ability of different organs.
Stem Cell Research and Treatment for immune system disease as well as central nervous system diseases are proved to be effective. If you have such problems and need a new treatment method, you can contact me via email. stemcelltech.cn@gmail.com

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